abstract |
IT REFERS TO A PROCESS THAT INCLUDES: REACTION OF 7-METOXY-1-NAPHTHOL, ON WHICH IT IS CONDENSED, IN THE PRESENCE OF PALADIUM WHERE THE HYDROXI GROUP IS TRANSFORMED INTO AN OUTGOING GROUP LIKE HALO, TOSILATE OR TRIFLUOROMETHANE CHUESULPHONATE AND CHUESULPHONATE 2 -R, WHERE R IS ACETAMIDE O (a); R´ AND R´´ ARE EACH ONE ALKYL (C1-C6) OR TOGETHER FORMING ALKYLENE (C2-C3) TO FORM THE COMPOUND (IV), WHICH IS SUBMITTED TO A CATALYTIC HYDROGENATION AND THEN THROUGH A BASIC OR ACID HYDROLYSIS AND REACTION WITH THE SODIUM ACETATE AND ACETIC ANHYDRIDE GIVES RISE TO THE AGOMELATIN COMPOUND. SAID COMPOUND IS USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM |