| abstract |
REFERS TO COMPOUNDS DERIVED FROM N- (2-AMINO-PHENYL) -ACRYLAMIDE OF FORMULA (I), WHERE R1 IS H, LOWER AQLUIL, CYCLOALKYL, ARYL, AMONG OTHERS; R2, R3 AND R4 ARE EACH H, HALO, LOWER RENT, AMONG OTHERS. SELECTED COMPOUNDS ARE: (E) -N- (2-AMINO-PHENYL) -3- {4 - [(4-CYCLOPROPYL-PHENYLCARBAMOIL) - ((S) -3-HYDROXY-PYRROLIDIN-1-IL) -MEthyl] -PHENYL} -ACRYLAMIDE; (E) -N- (2-AMINO-PHENYL) -3- {4 - [(4-CHLORO-PHENYLCARBAMOYL) - (3-DIETHYLAMINO-PYRROLIDIN-1-IL) -MEthyl] -PHENYL} -ACRYLAMIDE; (E) -N- (2-AMINO-PHENYL) -3- {4 - [(4-BROMO-PHENYLCARBAMOIL) - ((S) -3-HYDROXY-PYRROLIDIN-1-IL) -methyl] -PHENYL} - ACRYLAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND ITS PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF HISTONE DESACETILASE (HDAC), UTLES IN THE TREATMENT OF DISEASES SUCH AS CANCER IN HUMANS AND ANIMALS |