abstract |
IT REFERS TO COMPOUNDS DERIVED FROM FORMULA (1) CYCLOHEXYL DIAMINES, WHERE Y1, Y1 ', Y2, Y2', Y3, Y3 ', Y4 AND Y4' ARE EACH H, F, NO2, AMONG OTHERS; Q IS -R0; R0 IS ALIPHATIC (C1-C8), CYCLOALIPHATIC (C3-C12), ARYL, AMONG OTHERS; X ES = O, = CR6R7, = N-R6; R6 AND R7 ARE EACH H, HALO, -CHO, AMONG OTHERS; R1 AND R2 ARE EACH H, -R0, AMONG OTHERS; R3 IS R0; R4 IS H, -C (= O) R0, R0; R5 IS H, -CN, -C (= O) OH, AMONG OTHERS. SELECTED COMPOUNDS ARE: (S) -2- (4-DIMETHYLAMINE) -4-PHENYL CYCLOHEXYLAMINE) -3- (1H-INDOL-3-IL) PROPANAMIDE; (S) -2- (4-DIMETHYLAMINE) -4-PHENYL CYCLOHEXYLAMINE) -3- (1H-INDOL-3-IL) -N, N-DIMETHYLPROPANAMIDE; 5 - ((S) -1- (4- (DIMETHYLAMINE) -4-PHENYL CYCLOHEXYLAMINE) -2- (1H-INDOL-3-IL) ETHYL) -1,3,4-OXADIAZOL-2 (3H) -ONE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE RELATED TO THE OPIODE u RECEPTOR AND THE ORL-1 RECEPTOR, BEING USEFUL IN THE TREATMENT OF PAIN, ANOREXIA, ALZHEIMER'S DISEASE, AMONG OTHERS |