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publicationDate 2009-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PE-20091689-A1
titleOfInvention 4-AMINOCICLOHEXANE DERIVATIVES SUBSTITUTED WITH ACTIVITY ON µ AND ENT-1 RECEPTORS
abstract REFERRED TO A 4-AMINOCICLOHEXAN DERIVATIVE OF FORMULA (1), WHERE Y1, Y1 ', Y2, Y2', Y3, Y3 ', Y4 AND Y4' ARE H, F, CHO, CN, AMONG OTHERS; R1 AND R2 ARE H, R0, AMONG OTHERS; R0 IS AN ALIPHATIC GROUP OF 1 TO 8 CARBONS, A CYCLOALIFATIC GROUP OF 3 TO 12 CARBONS, ARYL, AMONG OTHERS; R3 IS R0; X IS O, S O NRA; RA IS H, R0, S (= O) 0-2R0, AMONG OTHERS; RB IS H, R0, -C (= O) R0, -C (= O) H, AMONG OTHERS; n IS 0 OR AN INTEGER FROM 1 TO 12. PREFERRED COMPOUNDS ARE: 1- (IMINO (1-METHYL-1H-INDOL-2-IL) METHYL) -N1, N1, N4, N4-TETRA-METHYL-4-PHENYL CYCLOHEXANE -1,4-DIAMINE, BIS (2-HYDROXYPROPANE-1,2,3-TRICARBOXYLATE), 4- (DIMETHYLAMINO-4-PHENYL-1- (PYRROLIDIN-1-IL) CYCLOHEXYL) - (1-METHYL-1H- INDOL-2-IL) METHANONE, 1,4-BIS (DIMETHYLAMINE) -4-PHENYL CYCLOHEXIL) (1-METHYL-1H-INDOL-2-IL) METHANONE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE AFFINITY FOR THE OPIODES µ AND ORL-1 RECEPTORS AND ARE USEFUL IN THE TREATMENT OF PAIN, ANXIETY, DEPRESSIONS, AMONG OTHERS
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priorityDate 2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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