| abstract |
REFERRED TO A COMPOUND OF FORMULA (I), WHERE B IS AN AROMATIC RING OF 6 MEMBERS, OPTIONALLY WITH 1-3 HETEROTATOMES OF N; AND WHERE THE B RING CAN BE FUSED TO ARILO, HETEROARILO, HETEROCICLO, AMONG OTHERS; L1 IS C3-C6 CYCLOALKYLENE, C1-C5 ALKYLENE; L2 IS A BOND, C3-C6 CYCLOALKYLENE, C1-C5 ALKYLENE; ONE OF V O T IS N AND THE OTHER IS CR3; Q IS N, CR3; R1 IS ARYL, HETEROARILO, HETEROCICLILO, AMONG OTHERS; R2 IS H, HALO, AMINO, AMONG OTHERS; R3 IS H, HALO, AMINO, ACILAMINO, AMONG OTHERS; R4 IS ARYL, HETEROARYL, CYCLOALKYL, AMONG OTHERS. THE SELECTED COMPOUNDS ARE: 2- (2-FLUORO-PHENYL) -5- (4-TRIFLUOROMETOXY-BENZYL) -5H-IMIDAZINE [4,5-D] PYRIDAZINE; 5- [6- (2,4-BIS-TRIFLUOROMETHYL-PHENYL] -PYRIDAZIN-3-ILMEthyl] -2- (2,3-DIFLUORO-PHENYL) -5H-IMIDAZO [4,5-D] PYRIDAZINE; 2- (2,3-DIFLUORO-PHENYL) -5- [6- (4-ETOXY-PHENYL) -PYRIDAZIN-3-ILMETYL] -5H-IMIDAZINE [4,5-D] PYRIDAZINE; AMONG OTHERS. ALSO REFERS TO A METHOD OF PREPARATION AND A PHARMACEUTICAL COMPOSITION SAID COMPOUND HAS ACTIVITY ON VIRUSES OF THE FLAVIVIRIDAE FAMILY AND IS USEFUL IN THE TREATMENT OF HEPATITIS B |