| abstract |
IT REFERS TO AQUEOUS SOLUTIONS FOR STORAGE STABILIZED DIHYDROPTERIDINONES FOR INFUSION OR INJECTIONS, INCLUDING: i) AN ACTIVE PRINCIPLE OF FORMULA (I), WHERE R1 IS H; R2 IS X2-ETHYL; R3 IS 1-X3-CYCLOPENTILO; R4 IS X4-O-CH3; Ln-R5m IS N-METHYL-4-X5-PIPERAZINE; X2, X3, X4 AND X5 ARE EACH LINK IN POSITION TO THE GENERAL FORMULA; m IS 1-2; n IS 1, WHICH IS FOUND IN A QUANTITY OF 0.1-10 mg / mL OF INFUSIBLE OR INJECTABLE SOLUTION; ii) AN ACID OR MIXTURE OF ACIDS SUCH AS HYDROCHLORIC ACID, ACETIC ACID, PHOSPHORIC ACID, AMONG OTHERS, SUFFICIENT TO DISSOLVE ACTIVE SUBSTANCE AND TO ACT AS A STABILIZER, WHICH IS FOUND IN A 3: 1 ACTIVE PROPORTION; AND iii) OTHER EXCIPIENTS SUCH AS EDTA, DEXTROSE, NaCl OR MANNITOL. ALSO REFERS THAT THE SOLUTION HAS A pH OF 2.4-5.3 BEING USEFUL IN THE ONCOLOGICAL TREATMENT OF RAPIDLY GROWING CANCER |