http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20091393-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_658df3b9d24eb5224b37aaf605741db6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12b2e3f403ca8c7ed66761820cbe342b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c7f506372cb48f8479541cf3253e563 |
| publicationDate | 2009-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PE-20091393-A1 |
| titleOfInvention | GLUCAGON ANTAGONISTS |
| abstract | REFERRING TO GLUCAGON ANALOGS, INCLUDING: I) SEQ ID No. 42 OR OXI DERIVATIVE FROM IT, CONTAINING: i) AMINO ACID FROM END C HAS AN AMIDA GROUP INSTEAD OF THE CARBOXYL ACID GROUP THAT IS PRESENT IN THE NATIVE AMINO ACID; ii) THE AMINO ACID OF SEQ ID NO. 19 FUSED TO THE AMINO ACID OF THE CARBOXI END OF SEQ. ID No. 42; iii) HYDROPHYL GROUP (POLYETHYLENE GLYCOL) JOINED IN COVALENT FORM TO AN AMINO ACID RESIDUE IN POSITION 11, 16 OR 19 OF SEQ ID Nº 42, OR IN THE AMINO ACID OF END N OR C OF GLUCAGON ANTAGONIST; II) SEQUENCE OF AMINO ACIDS OF NATIVE GLUCAGON MODIFIED BY ELIMINATING TWO TO FIVE AMINO ACID RESIDUES FROM END N OF SEQ ID NO 1, WHERE SUCH SEQUENCE HAS UP TO THREE AMINO ACID MODIFICATIONS; III) GLUCAGON ANTAGONIST OF STRUCTURE A-B-C, WHERE (A) IS SELECTED FROM a) LACTIC PHENYL ACID (PLA); b) OXY DERIVATIVE OF PLA Y; c) PEPTIDE OF 2 TO 6 CONSECUTIVE AMINO ACIDS WHERE TWO CONSECUTIVE AMINO ACIDS OF THE PEPTIDE ARE UNITED THROUGH AN ESTER OR ETHER LINK; (B) REPRESENTS AMINO ACIDS i AT 26 SEQ ID NO: 1, WHERE i IS 3, 4, 5, 6 OR 7, WHICH OPTIONALLY INCLUDES AMINO ACID MODIFICATIONS; AND (C) WHICH IS SELECTED FROM X, X-Y, X-Y-Z, X-Y-Z-R10, WHERE X IS Met, Leu OR Nle; AND IT IS Asn OR AMINO ACID WITH A CHARGE; Z IS Thr, Gly, Cys, AMONG OTHERS, R10 IS SELECTED FROM THE GROUP FORMED BY SEQ. ID. Nº 19-21 AND 53. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF HYPERGLYCAEMIA (DIABETES) |
| priorityDate | 2007-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.