| abstract |
REFERRING TO A FORMULATION CONTAINING: A) FROM 1 MG / ML TO 150 MG / ML OF A TYPE II ANTI-CD20 ANTIBODY, B) OPTIONALLY FROM 0.001 TO 1% W / V OF A TENSOACTIVE SUCH AS POLYSORBATE 20, MONOOLEATE OF POLYOXYETHYLENE (20) -SORBITE, AMONG OTHERS, C) FROM 1 TO 100 mM OF A BUFFER SUCH AS L-HISTIDINE, WHERE THE FORMULATION HAS A pH of 4.5 to 7.0 AND, ADDITIONALLY, IT MAY CONTAIN A QUANTITY BETWEEN 5 mM to 350 mM OF ISOTONIC AGENTS SUCH AS SODIUM CHLORIDE, POTASSIUM CHLORIDE, GLYCERIN, AMONG OTHERS AND OF NaCl, KCl, GLYCERIN, AMONG OTHERS, WHICH IS FOUND IN THE COMPOSITION; AND BETWEEN 25 mM to 500 mM OF SUGARS SUCH AS TREHALOSE, SACROSE, LACTOSE, AMONG OTHERS. SUCH COMPOSITION IS PRESENTED IN LIQUID FORM, LYOPHILIZED OR IN RECONSTITUTED LIQUID FORM AND IS USEFUL IN THE TREATMENT OF BREAST CANCER, COLORECTAL CANCER, PROSTATE CANCER, AMONG OTHERS |