| abstract |
IT REFERS TO A PHARMACEUTICAL FORMULATION THAT INCLUDES: A) A MONOCLONAL ANTIBODY IgG1 IN A CONCENTRATION OF 10 mg / mL TO 250 mg / mL; B) A HISTIDINE-ACETATE SHOCK ABSORBER THAT REDUCES THE AGGREGATION OR DEAMIDATION OF SAID ANTIBODY, WITH A pH OF 5.5 to 6.5; C) A SACRED SUCH AS TREHALOSE OR SUCROSA IN AN AMOUNT OF 60mM to 250mM; AND D) POLYSORBATE 20 IN AN AMOUNT OF 0.01% TO 0.1%. WHERE THE ANTIBODY AGGGLUTATES WITH AN ANTIGEN SUCH AS HER2, CD20, DR5, IgE, OR VEGF. SUCH FORMULATION IS USEFUL FOR THE TREATMENT OF PSORIASIS, ENDOMETRIOSIS, GASTROINTESTINAL ULCERS, ALLERGIC RHINITIS, CANCER |