| abstract |
REFERRING TO AN ANALOGUE COMPOUND OF SOMATOSTATIN OF FORMULA (II), WHERE R1 IS C2-C6-NR3R4 ALKYLENE, C2-C6-GUANIDINE ALKYLENE OR C2-C6-COOH ALKYLENE; R3 AND R4 ARE H, C1-C4 ALKYL, AMONG OTHERS; R2 IS Z1-CH2-R5, -CH2-CO-O-CH2-R5, AMONG OTHERS; Z1 IS OXYGEN OR SULFUR; R5 IS PHENYL, AMONG OTHERS; R11 AND R12 ARE AN AMINO PROTECTIVE GROUP. COMPOUND (II) IS SELECTED FROM H-Tyr (Bzl) -Phe- (2S, 4R) -4- (Boc-NH-CH2-NH-CO-O) -Pro-DPhg-DTrp (Boc) -Lys ( Boc) -OH, H-Tyr (Bzl) -Phe- (2S, 4R) -4- (Boc-NH-CH2-NH-CO-O) -Pro-Phg-DTrp (Boc) -Lys (Boc) - OH Y H-Tyr (Bzl) -Phe- (2S, 4R) -4- (Boc-NH-CH2-NH-CO-O) -Pro-Phg-D-Trp (Boc) -Lys (Boc) -OH OR A SALT OF THE SAME. IT IS ALSO REFERRED TO A PREPARATION PROCEDURE |