http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20091041-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cf7f3f36d20185ce15a2d1f04d5fdc1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D12-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 |
| filingDate | 2008-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a600dfd31b585907bc2df58c8b2e32d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_855b8625af28fa954dddaf685013e031 |
| publicationDate | 2009-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PE-20091041-A1 |
| titleOfInvention | SOLID DISPERSION PRODUCT CONTAINING A COMPOUND BASED ON N-ARYL UREA |
| abstract | REFERRED TO A SOLID DISPERSION THAT INCLUDES: A) AN ACTIVE PEOPLE OF FORMULA I, WHERE X1 IS N, CR1; X2 IS N, CR2; X3 IS N, CR3, CR3; X4 IS UNION, N, CR4; X5 IS N, C; Z1 IS O, NH, S; Z2 IS UNION, NH, O; Ar1 IS INDAZOLE, ISOQUINOLIN SUBSTITUTED; R1, R3, R5, R6 AND R7 ARE EACH H, ALCOXY, ALKYL, ALKYLTIO, AMONG OTHERS; R2 AND R4 ARE EACH H, ALKENYL, ALCOXY, ALKYLCARBONYL, AMONG OTHERS; R8a IS ABSENT OR IS H, RENT; R8b IS ABSENT OR IS H, ALCOXI, HALOGEN, AMONG OTHERS; B) ACCEPTABLE MATRIX FORMING AGENT FOR PHARMACEUTICAL USE SELECTED AMONG POLY N-VINYLPYRROLIDONES, VINYL ACETATE, N-VINYL PYRROLIDONE COPOLYMERS AND COMBINATIONS OF THE SAME; C) A COMBINATION OF 2 OR MORE ACCEPTABLE SURFACTANTS FOR PHARMACEUTICAL USE OF PREFERENCE ALPHA-TOCOPHERYL SUCCINATE POLYETHYLENE GLYCOL AND POLALKOXYLATED GLYCERIDE D) AT LEAST ONE SOLVENT. THE MASS RATIO BETWEEN THE ACTIVE AGENT AND MATRIX FORMING AGENT IS 0.1: 1 AND 1: 3. A PREFERRED ACTIVE AGENT IS: N- (5-TERT-BUTYL-2,3-DIHYDRO-1H-INDEN-1-IL) -N'-5-ISOQUINOLINYLUREA. SAID DISPERSION PRODUCT ALLOWS A SOLID FORMULATION OF LOW SOLUBILITY ACTIVE AGENTS WITH HIGH DRUG CONCENTRATION AND ACCEPTABLE BIODAVAILABILITY |
| priorityDate | 2007-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.