| abstract |
REFERRING TO A HETEROCYCLIC COMPOUND OF FORMULA (I), WHERE R1 IS H; R2 IS H O AMINO; A IS CR3; B IS CR3a O N; Ar 'IS A GROUP (a), AN ARYL OF 6 TO 14 CARBONS, A HETEROARYL GROUP OF 5 TO 10 MEMBERS, AMONG OTHERS; E IS CH O N; R3 AND R3a ARE H, C1-C6 ALKYL, C1-C6 HALOALKYL, AMONG OTHERS; R5 IS OH, C1-C6 ALKYL, C1-C6 HALOALKYL, AMONG OTHERS; R6 IS H, HALO, OH, CYANE, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5- (2-AMINO-4-METHYL-PYRIMIDIN-5-IL) -2-CHLORINE-N- (3-CYAN-PHENYL) -BENCENSULFONAMIDE, 5- (2-AMINO-4-METHYL-PYRIMIDIN -5-IL) -2-BROMO-N-PHENYL- (2-HYDROXY-ETHYL) -BENCENSULFONAMIDE, 5- (2-AMINO-2-METHYL-PYRIMIDIN-5-IL) -2-BROMINE-N-PROPYL- BENCENSULFONAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS INHIBIT THE ENZYME OF PHOSPHATIDYLINOSITOL 3-KINASE (P1 3-KINASE), PARTICULARLY, GAMMA-ISOFORM (p110 GAMMA), AND ARE USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, IN THE PYRHEA, RESPIRATORY |