| abstract |
REFERRING TO A DERIVATIVE TO A PIRAZINONE DERIVATIVE OF FORMULA (I), WHERE R1, R1a AND R2 ARE H, C1-C6 ALKYL, C1-C6 ALCOXY, CF3, HALO AND CN; R3 AND R4 ARE H, C1-C6 ALKYL, OH, CF3, CN, AMONG OTHERS; R5 IS H, C3-C7 CYCLOALKYL, ARYL, AMONG OTHERS; R6 IS H, C1-C6 ALKYL, C1-C6 ALCOXY, C3-C7 CYCLOALKYL, AMONG OTHERS; R7 IS H, C1-C6 ALKYL, C1-C6 ALCOXY, C3-C7 CYCLOALKYL, ARYL. PREFERRED COMPOUNDS ARE: N-CYCLOPROPYL-4-METHYL-3- [3 - [[1-METHYL-1- [2- [2- (METHYLAMINO) ETHOXY] PHENYL] ETHYL] AMINO] -2-OXO-1 (2H ) -PYRAZINIL] -BENZAMIDE, N-CYCLOPROPYL-4-METHYL-3- [3 - [[1- [2- [2- (METHYLAMINO) ETHOXY] PHENYL] CYCLOPROPYL] AMINO] -2-OXO-1 (2H) -PYRAZINYL] -BENZAMIDE, N-CYCLOPROPYL-3-FLUORO-5- [3 - [[1- [2- [2 - [(2-HYDROXYETHYL) AMINO] ETOXY] PHENYL] -1-METHYLOPROPYL] AMINO] -2 -OXO-1 (2H) -PIRAZINYL] -4-METHYL-BENZAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE INHIBITING ACTIVITY OF p38 KINASE AND ARE USEFUL IN THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT, BONES AND JOINTS, PAIN, OF THE SKIN, AMONG OTHERS |