| abstract |
REFERS TO A COMPOUND OF FORMULA 1, WHERE X IS -O-, -S-, -S (O2) -, AMONG OTHERS; ---- IS OPTIONAL LINK; Y, Z ARE EACH N, C; Q IS RING OF 5-8 MEMBERS FUSED WITH A1 AND Q1; Q1 IS A RING OF 5-7 MEMBERS WITH A HETEROATOME SELECTED FROM N, O, S (O) AND S (O2) FUSED WITH Q; L1 IS HALOGEN, ALKYL, -CN, -CF3, -O- (C1-C6 ALKYL), AMONG OTHERS; Ar IS ARYL SUBSTITUTED OR NOT, HETEROARYL IS SUBSTITUTED OR NOT. A PREFERRED COMPOUND IS (5aR, 13aS) -11bR - [(4-CHLOROPHENYL) SULFONIL] -8,11-DIFLUORO-2,3,5a, 6,11b, 12,13,13a-OCTAHYDRO [1] BENZOPYRANE [4 ', 3': 5.6] PYRID [1,2-c] PYRIMIDIN-4 (1H) -ONE. SUCH COMPOUNDS ARE USEFUL GAMMA SECRETASE INHIBITORS IN THE TREATMENT OF ALZHEIMER |