abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R1 IS ARYL SUBSTITUTED OR NOT, HETEROARYL IS SUBSTITUTED OR NOT; R2 IS HALOALKYL SUBSTITUTED OR NOT; R3 IS ARYL SUBSTITUTED OR NOT, HETEROARYL IS SUBSTITUTED OR NOT. PREFERRED COMPOUNDS ARE: 5-CHLORO-N- [3,3,3-TRIFLUORO-1- (HYDROXIMETHYL) -2-PHENYLPROPYL] THIOFEN-2-SULFONAMIDE; 5-CHLORO-N - [(1S, 2S) -2- (DIFLUOROPHENYL) -3,3,3-TRIFLUOR-1- (HYDROXIMETHYL) PROPYL] THIOFEN-2-SULFONAMIDE; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF THE PRODUCTION OF BETA AMYLOID, USEFUL IN THE TREATMENT OF ALZHEIMER |