| abstract |
REFERRED COMPOUNDS OF FORMULA (I): WHERE R1 AND R3 TOGETHER FORM 5-8 MEMBER HETEROCYCLYL, SUBSTITUTED OR NOT WITH 1-5 R21 GROUPS, 5-8 MEMBER HETEROCYCLENYL FUSED WITH ARYL OR HETEROARIL RING, AMONG OTHERS; R2 IS H, ALKYL, CYCLOALKYL, CYCLOALKENYL, ARYL, AMONG OTHERS; R3 WHEN IT DOES NOT JOIN R1 IT IS ARYL-, ARYLALKYL-, ALKYLARIL-, AMONG OTHERS; R4, R6, R7, R8 AND R9 ARE EACH H, ALKYL-, ALKENYL-, AMONG OTHERS; R10 IS LINK, RENT, ARYL, CYCLOALKYL, AMONG OTHERS. IT ALSO REFERS TO PREPARATION PROCEDURES AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE ACTIVITY AS GAMMA SECRETASE MODULATORS, USEFUL IN THE TREATMENT OF DISEASES AND DISORDERS RELATED TO THE CENTRAL NERVOUS SYSTEM SUCH AS ALZHEIMER, MILD COGNITIVE IMPAIRMENT (MCI), AMONG OTHERS |