| abstract |
REFERS TO NON-NUCLEOSIDIC COMPOUNDS DERIVED FROM UREA AND CARBAMATE OF FORMULA (I) WHERE X IS OR U NR2, WHERE R2 IS H, ALKYL (C1-C6), AMONG OTHERS; R1 IS HALOGEN, ALKYL (C1-C6), CYCLOALKYL (C3-C7), ALCOXY (C1-C6), AMONG OTHERS; R3 IS H, (C1-C6) ALKYL, PHENYL, AMONG OTHERS; Ar IS PHENYL SUBSTITUTED WITH HALOGEN, CN, HALOALKYL (C1-C6) OR ALKYL (C1-C6). PREFERRED COMPOUNDS ARE: 3- [6-BROMINE-2-FLUORO-3- (2-OXO-2,3-DIHYDRO-BENZOIMIDAZOL-1-ILMETHYL) -PHENOXY] -5-CHLORO-BENZONITRILE, 3- [6-BROMINE -2-FLUORO-3- (2-OXO-2,3-DIHYDRO-IMIDAZO [4,5-b] PYRIDIN-1-ILMETHYL) -PHENOXY] -5-CHLORO-BENZONITRILE, 3- [6-BROMINE-2 -FLUORO-3- (2-OXO-2,3-DIHYDRO-IMIDAZO [4,5-c] PYRIDIN-1-ILMETHYL) -PHENOXY] -5-CHLORO-BENZONITRILE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF THE REVERSE TRANSCRIPTASE OF THE HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) AND ARE USEFUL IN THE TREATMENT OF AIDS |