| abstract |
REFERRED TO A CONJUGATE Comprising A CARRIER AND KALICHEAMICIN, WHERE THE KALICHEAMICIN IS COVALENTLY BOUND TO THE CARRIER AND THE CARRIER IS A MONOCLONAL ANTIBODY. SAID COVALENT LINK IS BROKEN WHEN ADDING A REDUCING AGENT SUCH AS DITIOTREITOL, DITIOERITRITOL, MERCAPTANE, GLUTATHIONE, AMONG OTHERS, WHICH ALLOWS THE DETECTION OF CALIQUEAMICIN IN A FLUID SAMPLE; AN ANTIOXIDANT SUCH AS ISOPROPYL ALCOHOL, BENZOIC ACID, SODIUM SULPHITE, PROPYL GALATE, AMONG OTHERS, IS ALSO ADDED TO SUCH SAMPLE. |