| abstract |
REFERS TO QUINOLINE-CARBOXAMIDE DERIVATIVES OF FORMULA (I) WHERE E IS A 3 TO 10 MEMBER HETEROCYCLIC; X IS NO C-R8; Q IS A COVALENT LINK, ALKENYL (C2-C10), ALKYNYL (C2-C10), AMONG OTHERS; J IS H, ALKYL (C1-C6), ALKYLEN (C0-C4) -O-CH2-FLUOROALKYLENE (C1-C3) -CH2-O-ALKYL (C1-C4), AMONG OTHERS; Z IS ALKYLENE (C0-C8), ALKENYL (C2-C10), ALKYLENE (C2-C10), AMONG OTHERS; A IS A COVALENT LINK, ALKYLENE (C3-C8), CYCLOALKYLENE (C3-C8) OR HETEROCYCLYL (C3-C15); B IS A COVALENT LINK, ALKENYL (C2-C10), ALKINYL (C2-C10), AMONG OTHERS; V IS HETEROCYCLYL OR N (R1) -HETEROCYCLYL (C3-C15); G IS A COVALENT LINK, ALKENYL (C2-C10), ALKINYL (C2-C10), AMONG OTHERS; M IS H, ALKYL (C1-C8), CYCLOALKYL (C3-C8), AMONG OTHERS; R1 IS H, (C1-C4) ALKYL, AMONG OTHERS; R2, R3, R4, R5, R6 AND R8 ARE EACH H, ALKYL (C1-C6), HALOGEN, CN, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: ETHYL ACID ESTER 4 - [(S) -4-CARBOXI-2 - ({4- [2- (4-HYDROXY-2-METOXYCARBONYL-PYRROLIDIN-1-IL) -2-OXO-ETOXY] -7-METHYL-QUINOLINE-2-CARBONYL} -AMINE) -BUTYRYL] -PIPERAZINE-1-CARBOXYL, ETHYL ACID ESTER 4 - [(S) -4-CARBOXY-2 - ({7-METHYL-4- [ 2-OXO-2- (2-OXO-PYRROLIDIN-1-IL) -ETOXY] -QUINOLINE-2-CARBONYL} -AMINE) -BUTYRIL] -PIPERAZINE-1-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF THE ADENOSINE 5'-DIPHOSPHATE RECEPTOR (ADP) OF P2Y12 PLATELETS, BEING USEFUL IN THE TREATMENT OF THROMBOEMBOLIC DISEASES OR RESTENOSIS |