abstract |
REFERS TO HETEROCYCLIC COMPOUNDS OF FORMULA (I) WHERE X1, X2, X3, X4, X5 AND X6 ARE EACH N, N-OXIDE OR CR1, WHERE R1 IS H, HALOGEN, CN, ALKYL (C1-C6), ALCOXI (C1-C6), AMONG OTHERS; R2 IS H, OH, HALOGEN, ALKYL (C1-C6), ALKYLTIO (C1-C6), AMONG OTHERS; X7 IS O, CH2, S, SO, AMONG OTHERS; R4 IS H, OH, ALCOXY (C1-C6), F, NH2, AMONG OTHERS; D IS A COMPOUND OF FORMULA (a) WHERE R9 IS CARBOXYL, ALCOXY (C1-C6) CARBONYL, AMINOCARBONYL, TETRAZOLE, AMONG OTHERS; R10 IS H, HALOGEN, OH, AMONG OTHERS; n IS 0 TO 3; p IS 0 O 1; C IS A COMPOUND OF FORMULA (b) WHERE Y1 IS CR6 OR N, WHERE R6 IS H, OH, HALOGEN, AMONG OTHERS; R7 IS H, HALOGEN, OH, (C1-C6) ALKYL, AMONG OTHERS; R8 IS ARYL (C6-C10), CYCLOALKYL (C3-C10), ARYL (C6-C10) -ALKYL (C1-C6), AMONG OTHERS; m IS 0 TO 3; q IT IS FROM 0 TO 2. THE PREFERRED COMPOUNDS ARE: ACID (3R, 4R) -4- (3-HYDROXY-3- (6-METOXYQUINOLIN-4-IL) PROPYL) -1- (3-PHENYL CYCLOBUTYL) PIPERIDIN-3- CARBOXYL, ACID (3R, 4R) -4- (3- (3-FLUORO-6-METHOXYQUINOLIN-4-IL) -3-HYDROXYPROPYL) -1- (3-PHENYL CYCLOBUTYL) PIPERIDIN-3-CARBOXYL, ACID (3R, 4R) -4- (3- (3-CHLORO-6-METOXYQUINOLIN-4-IL) -3-HYDROXYPROPYL) -1- (3-PHENYL CYCLOBUTIL) PIPERIDIN-3-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF BACTERIAL INFECTIONS |