| abstract |
REFERS TO A MODIFIED MICROORGANISM WITH THE ABILITY TO PRODUCE ONE MORE TYPES OF L-AMINO ACIDS, SUCH AS L-GLUTAMIC ACID, L-GLUTAMINE, L-PROLINE, L-ORNITHINE, L-CITRULINE AND L-ARGININE, DUE TO THE INCREASE OF THE SYNTHESIS ACTIVITY OF a-CETOGLUTARATE; SAID INCREASE IS THROUGH THE INCREASE IN THE NUMBER OF COPIES OF THE GENE THAT CODES IT OR MODIFICATION OF THE SEQUENCE OF CONTROL OF THE EXPRESSION OF THE GENE; WHERE THE MODIFIED MICROORGANISM IS SELECTED FROM ESCHERICHIA, ENTEROBACTER, PANTOEA, KLEBSIELLA AND SERRATIA AND HAS INCREASED THE ACTIVITY OF FERREDOXIN NADP + REDUCTASE, THE ACTIVITY OF SYNTHESIS OF PIRUVATE, AND THE ACTIVITY OF a-DISHUVATE CETHUIDROGEN. REFERS ALSO TO a-CETOGLUTARATE CODING GENES THAT CODE A POLYPEPTIDE; NUCLEOTIDIC SEQUENCES INCLUDING A DNA, MEDIA AND CONDITIONS OF MICROBIOLOGICAL CULTURE AND A PROCEDURE FOR THE PREPARATION AND / OR ACCUMULATION OF L-AMINO ACIDS |