| abstract |
REFERRED TO A COMPOUND DERIVED FROM PIRROL OF FORMULA (I), WHERE R1 IS AN ARYL OR HETEROARYL GROUP SUCH AS PHENYL, FURILE, TIENEYL, AMONG OTHERS; R2 IS HALOGEN, CYANE, ACIL, HALO ALKYL, AMONG OTHERS; R3 IS ALKYL, ACILO, HYDROXY, AMINO, AMONG OTHERS; R4 AND R5 ARE ALKYL, ACILO, OH, AMONG OTHERS; R6 AND R6 'ARE H OR ALKYL; n IS AN INTEGER FROM 0 TO 3. PREFERRED COMPOUNDS ARE: 1- [5- (2-FLUOROPYRIDIN-3-IL) -1- (FENYLSULFONIL) -1H-PYRROL-3-IL] -N-METHYLMETHANAMINE, 1- [ 4-FLUORO-5- (2-FLUOROPYRIDIN-3-IL) -1- (PYRIDIN-3-ILSULFONIL) -1H-PYRROL-3-IL] -N-METHYLMETHANAMINE, 1- [5- (2-CHLOROPYRIDIN-3 -IL) -1- (PHENYLSULFONIL) -1H-PYRROL-3-IL] -N-METHYLMETHANAMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE INHIBITORY ACTIVITY ON THE PROTON PUMP AND ARE USEFUL IN THE TREATMENT OF ULCERS, GASTRITIS, ESOPHAGITIS, FUNCTIONAL DYSPEPSIA, AMONG OTHERS |