abstract |
REFERRED TO A COMPOUND OF FORMULA (I '), WHERE RINGS A AND B ARE THE SAME OR DIFFERENT AND EACH ONE IS A MONOCYCLE OF 5 TO 7 MEMBERS; THE D 'RING IS A SINGLE CYCLIC AROMATIC HETEROCYCLE OF 5 MEMBERS; Y 'IS N O C; X IS A SPACER THAT HAS 1 TO 4 ATOMS IN THE MAIN CHAIN; W IS -CONR1aS (O) mR2, -NR1bS (O) mNR1aCOnR2, -ONR1aCONR1cR2, AMONG OTHERS; R1a AND R1b ARE H OR C1-C6 ALKYL; R1c IS H, C1-C6 ALKYL OR C1-C6 ALCOXY; R2 IS H, A HYDROCARBON OR HETEROCYCLE GROUP; m AND n ARE 1 OR 2. PREFERRED COMPOUNDS ARE: (2E) -3- [1,3-DIMETHYL-5- (1H-PYRROLO [2,3-b] PYRIDIN-1-IL) -1H-PYRAZOLE-4 -IL] -N- (PENTILSULFONIL) ACRYLAMIDE, [(2- {1,3-DIMETHYL-5- [5- (TRIFLUOROMETHYL) -1H-PYRROLO [2,3-b] PYRIDIN-1-IL] -1H- PYRAZOLE-4-IL} ETHYL) SULFONYL] BUTYL CARBAMATE, (2E) -3- [5-CHLORO-1H-INDOL-1-IL) -1,3-DIMETHYL-1H-PIRAZOL-4-IL] -N - (PENTILSULFONIL) ACRYLAMIDE, AMONG OTHERS. IT IS ALSO REFERRED TO A PREPARATION PROCEDURE. SUCH COMPOUNDS HAVE PARTIAL AGONIST ACTIVITY ON THE GAMMA RECEPTOR IN RESPONSE TO THE GROWTH OF PEROXISOMES (PPAR GAMMA) AND ARE USEFUL AS HYPOGLYCEMICS, HYPOLIPIDEMICS, INSULIN SENSITIZERS |