| abstract |
REFERS TO COMPOUNDS DERIVED FROM AMIDE FROM FORMULA (I) WHERE A IS PYRIDYL, PHENYL, QUINOLINYL, NAPHTHYRIDINYL, AMONG OTHERS; R1a IS H, HALOGEN, (C1-C4) ALKYL, ALCOXY, OR TRIFLUOROMETHYL; R1b AND R1c ARE EACH H, HALOGEN, HYDROXY, HALOALKYL (C1-C4), AMONG OTHERS; R1d IS Cl, F, METHYL, CF3, OR CN; R2 IS ALKYL (C1-C4) - (R5) p, WHERE R5 IS H, HYDROXY, -OC (O) -ALKYL (C1-C6), -OC (O) O-ALKYL (C1-C6), BETWEEN OTHERS; p IS 1 TO 3; R2a IS PHENYL, ALKYL (C1-C6), ARYL-ALKYL (C1-C4), AMONG OTHERS, OPTIONALLY REPLACED WITH R3, WHERE R3 IS HALOGEN, CN, HALOALKYL (C1-C4), AMONG OTHERS. PREFERRED COMPOUNDS ARE: 4- {5-CHLORO-4- (4-CYANE-6-TRIFLUORomethyl-PYRIDIN-3-IL) ACID - [(2-FLUORO-6-METOXY-PHENYL) -MEthyl-CARBAMOYL] - PHENOXY} -BUTYRIC, 4-CHLORO-5- (4-CYANE-6-TRIFLUOROMETHYL-PYRIDIN-3-IL) -N- (2-METHOXY-PHENYL) -N-METHYL-2- [3- (2H-TETRAZOLE -5-IL) -PROPOXI] -BENZAMIDE, 4-CHLORO-3- (4-CYANE-6-TRIFLUORomethyl-PYRIDIN-3-IL) -N-METHYL-N- {2- [2- (1H-TETRAZOL- 5-IL) -ETOXY] -PHENYL} -BENZAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF THE GONADOTROPIN RELEASING HORMONE RECEPTOR (GnRH), BEING USEFUL IN THE TREATMENT OF ENDOMETRIOSIS, UTERINE FIBROIDS, DYSMENORRHEA, POLYCHISTIC OVARY DISEASE |