| abstract |
REFERS TO COMPOUNDS DERIVED FROM PYRAZOLOPYRIMIDINE OF FORMULA (Ia) WHERE R1 IS A COMPOUND OF FORMULA (i) WHERE X5 IS -O-, -CH2-O- OR -S (O) n; n IS 0 TO 2; R2 IS ARYL (C6-C14) OPTIONALLY SUBSTITUTED WITH HALOGEN, ALKYL (C1-C6), ALCOXY (C1-C6), AMONG OTHER SUBSTITUENTS, HETEROARYL, -HC = CH-ARYL (C6-C14), AMONG OTHERS; R3 IS H, ALKENYL (C2-C10), ALKINYL (C2-C10), ARYL (C6-C14), HYDROXYALKYL (C1-C6), AMONG OTHERS; R13 IS H, HALOGEN, ALKYL (C1-C6), ALKENYL (C2-C6), ALKINYL (C2-C6), AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 1- (4- {4-MORFOLIN-4-IL-1- [1- (PYRIDIN-3-ILCARBONYL) PIPERIDIN-4-IL] -1H-PYRAZOLO [3,4-d] PYRIMIDIN-6 -IL} PHENYL) -3-PYRIDIN-3-ILUREA, 1- (4- {4-MORFOLIN-4-IL-1- [1- (PYRIDIN-3-ILCARBONYL) PIPERIDIN-4-IL] -1H-PYRAZOLE [3,4-d] PYRIMIDIN-6-IL} PHENYL) -3- (3-THYENYL) UREA, 1- (4- {4-MORFOLIN-4-IL-1- [1- (PIRIDIN-3-ILCARBONIL ) PIPERIDIN-4-IL] -1H-PIRAZOLO [3,4-d] PYRIMIDIN-6-IL} PHENYL) -3-PYRIDIN-4-ILUREA, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF mTOR AND PHOSPHATIDYLINOSITOL-3 KINASE (PI3K), BEING USEFUL IN THE TREATMENT OF CANCER, ATHEROSCLEROSIS, ARTHRITIS, PSORIASIS |