abstract |
REFERS TO ADENINE-DERIVED COMPOUNDS OF FORMULA (1) WHERE A IS AROMATIC CARBOYCLE OR AROMATIC HETEROCYCLE; L1 IS A LINK OR ALKYLENE (C1-C6); L2 IS A LINK OR ALKYLENE (C1-C6) OPTIONALLY SUBSTITUTED WITH OH, NH2, ALKYLAMINE, AMONG OTHERS; R1 IS HALOGEN, ALKYL (C1-C6), ALKENYL (C2-C6), ALKYNYL (C2-C6), AMONG OTHERS; R2 AND R3 ARE EACH H, ALKYL (C1-C6), ALKENYL (C2-C6), CYCLOALKYL (C3-C8), AMONG OTHERS; X IS O, S, SO, SO2, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 6-AMINO-2-BUTOXI-9- (4-MORFOLIN-4-ILMETILBENZL) -7,9-DIHIDROPURIN-8-ONA, 6-AMINO-2-BUTOXI-9- (4-PIPERIDIN-1 -YLMETHYLBENZYL) -7,9-DIHYDROPURIN-8-ONA, 6-AMINO-2-BUTOXY-9- [4- (4-METHYLPIPERAZIN-1-ILMETHYL) BENZYL] -7,9-DIHYDROPURIN-8-ONA, BETWEEN OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ACTIVATORS OF THE Toll TYPE RECEPTOR (TLR7) BEING USEFUL IN THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS, ATOPIC DERMATITIS, CANCER |