abstract |
REFERRING TO A PYRROLOPYRIDINE COMPOUND OF FORMULA (I), WHERE n IS AN INTEGER FROM 0 TO 3; X IS HALOGEN, C1-C6 ALKYL, C3-C7 CYCLOALKYL, C (O) NR1R2, AMONG OTHERS; AND IT IS A HETEROARYL GROUP OPTIONALLY SUBSTITUTED WITH C3-C7 CYCLOALKYL, C1-C6 FLUOROALCOXYL, NITRO, HYDROXYL, NR1R2, AMONG OTHERS; R1 AND R2 ARE H, C1-C6 ALKYL, C1-C5 ARYLALKYLENE, AMONG OTHERS; W IS A CONDENSED BICYCLE GROUP OF FORMULA (a), WHERE A IS A HETERO CYCLE OF 5 TO 7 LINKS THAT INCLUDES HETEROATOMS SUCH AS O, NOS, OPTIONALLY REPLACED BY ONE OR SEVERAL H, C1-C6 ALKYL, C1-C6 FLUOROALKYL , AMONG OTHERS. PREFERRED COMPOUNDS ARE: N- (2-METHYL-BENZOTHIAZOL-5-IL) -5-FLUORO-1 [(4-PYRIDYL) METHYL] -1H-PYRROLO [2,3-b] PYRIDIN-2-CARBOXAMIDE, N- (1,2-DIMETHYL-1H-BENZYMIDAZOLE-5-IL) -5-FLUORO-1 - [(4-PYRIDYL) METHYL] -1H-PYRROLO [2,3-b] PYRIDIN-2-CARBOXAMIDE, N- ( 2-METHYL-BENZOTHIAZOL-5-IL) -1- (3-PYRIDYL) -1H-PYRROLO [2,3-b] PYRIDIN-2-CARBOXAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF TRPV1 (VR1) RECEPTORS AND ARE USEFUL IN THE TREATMENT OF PAIN, INFLAMMATION, NEUROPATHIC PAIN, AMONG OTHERS |