| abstract |
REFERS TO COMPOUNDS DERIVED FROM AZIRIDINE OF FORMULA (I) WHERE R IS 2,4,6-TRIISOPROPYL-PHENYL-SULPHONYL, 3,4-DIMETOXY-PHENYL-SULFONYL, PHENYL-SULPHONYL, AMONG OTHERS; R1 AND R4 ARE EACH H, ALKYL (C1-C6), CYCLOALKYL (C3-C20), ARYL (C6-C12), HETEROARYL OF 5 TO 14 ATOMS IN THE RING, AMONG OTHERS; L IS A SUITABLE CONNECTOR FOR COUPLING WITH RADICAL ADDRESSING AGENT SUCH AS ALKYL (C1-C6), CYCLOALKYL (C3-C20), ALKENYL (C2-C6), ARYL (C6-C12), AMONG OTHERS; B IS THE ADDRESSING AGENT SUCH AS PEPTIDES, PEPTIDOMIMETICS, SMALL MOLECULES AND OLIGONUCLEOTIDES. PREFERRED COMPOUNDS ARE: GLY-VAL-BALA-PHE-GLY-AMIDE OF ACID 1- (TOLUEN-4-SULFONIL) -AZIRIDIN-2-CARBOXYLICO, GLY-VAL-BALA-PHE-GLY-AMIDE OF ACID 1- (2 , 4,6-TRIISOPROPIL-BENCENSULFONIL) -AZIRIDIN-2-CARBOXILICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE FLUORATED AND MARKED, BEING USEFUL FOR THE IMAGING DIAGNOSIS OF TUMORS, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS FOR POSITRON EMISSION TOMOGRAPHY |