abstract |
REFERRING TO A COMPOUND DERIVED FROM INDOLE AND BENZOFURAN FROM FORMULA (I) OR (II), WHERE m IS AN INTEGER FROM 0 TO 3; n AND p ARE 1 0 2; X IS O, S, NR7; Y IS N O CH IF p IS 2 E Y IS CH IF p IS 1; Ar IS ARYLUS, HETEROARYL, AMONG OTHERS; R1 IS H O C1-C6 ALKYL; R2 IS HALOGEN, C1-C6 ALKYL, C1-C6 ALCOXY, AMONG OTHERS; q IS 0 O 1; r IS AN INTEGER FROM 0 TO 2; R3 AND R4 ARE H OR C1-C6 ALKYL; R5 IS NITRILE, -C (O) -NReRf, SO2-Rg, AMONG OTHERS; Re AND Rf ARE H O C1-C6 ALKYL; Rg C1-C6 ESALKYL; R6 IS H, HALOGEN, C1-C6 ALKYL, AMONG OTHERS; R7 IS H, C1-C6 ALKYL OR C1-C6 HETEROALKYL. THE PREFERRED COMPOUNDS ARE: 1-BENZYL-4-PIPERAZIN-1-IL-1H-INDOL-2-CARBOXYL ACID DIMETHYLAMIDE, 1-BENZYL-4-PIPERIDIN-4-IL-1H-INDOL-2-CARBOXYL ACID AMIDE, 1-BENZYL-4-PIPERAZIN-1-IL-1H-INDOL-2-CARBOXYL ACID METHYLAMIDE, AMONG OTHERS. SUCH COMPOUNDS HAVE SELECTIVE AFFINITY WITH 5-HT RECEPTORS AND ARE USEFUL IN THE TREATMENT OF PARKINSON'S DISEASE, ANXIETY, DEPRESSION, AMONG OTHERS |