abstract |
REFERRING TO A COMPOUND DERIVED FROM INDOLINONE, BENZHIMIDAZOLONE OR BENZOXAZOLONE FROM FORMULA (I), WHERE E1 IS N OR CH; E2 IS NR, O O CRaRb; R IS H, C1-C3 ALKYL, CH2-COOH, CH2-COO-C1-C6 ALKYL; Ra AND Rb ARE H O C1-C3 ALKYL; THE DOTTED LINE INDICATES AN OPTIONAL DOUBLE LINK; r IS AN INTEGER FROM 0 TO 2; r 'AND r' 'ARE AN INTEGER FROM 1 TO 3; X IS H, HALOGEN, HALOGEN, OXO; = NOR '; R 'IS H, C1-C6 ALKYL, C3-C6 CYCLOALKYL, AMONG OTHERS; m AND n ARE AN INTEGER FROM 0 TO 2; A IS C1-C6 ALKYL, C2-C6 ALKYL, A CARBOCYCLE, AMONG OTHERS; R1 IS H, HALOGEN, CN, C (O) R5, AMONG OTHERS; R2 IS H, HALOGEN, CF3, C1-C3 ALCOXY, C1-C3 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 1- {1- [2- (4-CHLOROPHENYL) -2-OXOETHYLPIPERIDIN-4-IL} -2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOL-5-CARBOXYL ACID METHYLAMIDE, 1- {1- [2- (4-CHLOROPHENYL) -2-OXOETHYL] PIPERIDIN-4-IL} -6-FLUORO-2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYL ACID, METHYL ESTER FROM 1- {1- [2- (4-CHLOROPHENYL) -2-OXOETHYL] PIPERIDIN-4-IL} -6-FLUORO-2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYL ACID, BETWEEN OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE MODULATORS OF SERINE PALMITOYLTRANSFERASE AND ARE USEFUL IN THE TREATMENT OF TYPE 2 DIABETES, INSULIN RESISTANCE, METABOLIC SYNDROME, AMONG OTHERS |