| abstract |
REFERS TO COMPOUNDS DERIVED FROM BIS (NITROOXI) OF FORMULA (I) WHERE R IS A COMPOUND OF FORMULA (i), (ii), AMONG OTHERS; Y IS -Y1-Y2-Y3-Y4-Y5-, WHERE Y1 IS C (R1R2); R1 IS HO (C1-C4) ALKYL; R2 IS H, (C1-C4) ALKYL O -OC (O) (C1-C4) ALKYL; Y2 IS O, C (O), P (O) (OH) O CH2; Y3 IS O, C (O) O CH2; Y4 IS ABSENT OR IS O, CH2; Y5 IS ABSENT OR IS - (CH2) 1-2- (X) 0-1- (CH2) 0-1, WHERE X IS -O- OR -CR3R4-; R3 AND R4 ARE EACH H OR ALKYL (C1-C4). PREFERRED COMPOUNDS ARE: 1 - [({[(5S) -5,6-BIS (NITROOXY) HEXYL] OXI} CARBONYL) OXY] ETHYL 2-BUTYL-4-CHLORO-1 - {[2 '- (1H-TETRAZOLE -5-IL) BIPHENYL-4-IL] METHYL} -1H-IMIDAZOL-5-CARBOXYLATE, 1 - [({2- [2,3-BIS (NITROOXY) PROPOXI] ETOXY} CARBONYL) OXY] ETHYL 2-BUTYL -4-CHLORO-1 - {[2 '- (1H-TETRAZOLE-5-IL) BIPHENYL-4-IL] METHYL} -1H-IMIDAZOL-5-CARBOXYLATE, 1 - [({[3,3-DIMETHYL- 5,6-BIS (NITROOXY) HEXYL] OXI} CARBONYL) OXY] ETHYL 2-BUTYL-4-CHLORO-1 - {[2 '- (1H-TETRAZOL-5-IL) BIPHENYL-4-IL] METHYL} - 1H-IMIDAZOL-5-CARBOXYLATE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF THE ANGIOTENSIN II RECEPTOR, BEING USEFUL IN THE TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, KIDNEY FAILURE, ATHEROSCLEROSIS |