| abstract |
REFERRED TO AN ANTIBODY THAT JOINS STEAP-1 (SIX TRANSMEMBRANE EPITHELIAL ANTIGENS OF THE PROSTATE) INCLUDING ONE, TWO OR THREE HYPERVARIABLE HEAVY-CHAIN REGIONS (HVR) SELECTED FROM: 1) A HVR-H1 SEQUENCE CONTAINING AMINO ACIDS OF SEQUENCE IDENTIFIER NO. 14, 2) AN HVR-H2 CONTAINING THE AMINO ACID SEQUENCE OF SEQUENCE IDENTIFIER NO. 15 AND 3) AN HVR-H3 CONTAINING THE AMINO ACID SEQUENCE OF SEQUENCE IDENTIFIER NO. 16. ALSO REFERRED TO THIS AN IMMUNOCONJUGATE THAT INCLUDES AN ANTIBODY THAT COVALENTLY JOINES A CYTOTOXIC AGENT SUCH AS A TOXIN, A CHEMOTHERAPEUTIC AGENT, A FRACTION OF A PHARMACO, AN ANTIBIOTIC, AMONG OTHERS, WHERE SAID ABUSED FORM IS IMMUNOUSLY. THE DESCRIBED ANTIBODY, L IS A BINDER SUCH AS-6-PHENYLALANINE, VALINE-CITRULINE, MALEIMIDOPROPANOIL, AMONG OTHERS, AND D IS A FRACTION OF A DRUG SUCH AS AURISTATIN AND DOLASTATIN |