| abstract |
REFERRING TO A HETEROCICLIC COMPOUND OF FORMULA (I), WHERE a IS A HETEROARYL OR HETEROCYCLYL RING OF 6 TO 9 MEMBERS; X IS O O S; E IS CR5, NOT A CARBON SP2; R5 IS H, OH, AMINO, SULFONIL, AMONG OTHERS; Q IS NOT A CARBON SP2; THE RING b IS ARYL, HETEROARYL, AMONG OTHERS; R1 IS HALOGEN, OH, NITRILE, THIOL, AMONG OTHERS; R2 IS NITRILE, HALO, SULFONIL, AMONG OTHERS; R3 AND R4 ARE H, C1-C10 ALKYL, ARYL, AMONG OTHERS; W IS A COVALENT LINK, C1-C3 ALKYLENE, S (O) p, AMONG OTHERS; p IS 0.1 O 2; Y IS S, O, S (O), S (O) 2, AMONG OTHERS; Z IS CH (R10) O CH (R10) CH (R11); R10 AND R11 ARE C1-C6 ALKYL, C2-C6 ALKYL, HETEROARYL, AMONG OTHERS; m IS 0, 1 O 2; n IS 0 O 1. THE PREFERRED COMPOUNDS ARE: 4- (4-CHLORO-PHENOXY) -N- (1-HYDROXY-2-OXO-2,3,4,7-TETRAHIDRO-1H-AZEPIN-3- (R) -IL) -BENCENSULFONAMIDE, (1-HYDROXY-2-OXO-2,3,4,7-TETRAHYDRO-1H-AZEPIN-3- (R) -IL) -AMIDE OF 4'-CHLORO-BIPHENYL-4- ACID SULPHONIC, N- (1-HYDROXY-2-OXO-2,3,4,7-TETRAHYDRO-1H-AZEPIN-3- (R) -IL) -4-PHENOXY-BENCENSULFONAMIDE, AMONG OTHERS. IT IS ALSO REFERRED TO AN INTERMEDIARY COMPOUND OF COMPOUND (I). SUCH COMPOUNDS ARE INHIBITORS OF MATRIX METALOPROTEASES (MMP) AND ARE USEFUL IN THE TREATMENT OF INFLAMMATORY, CARDIOVASCULAR, NEUROLOGICAL DISEASES, AMONG OTHERS |