| abstract |
REFERS TO COMPOUNDS DERIVED FROM DIARYL, DIPYRIDINYL AND ARYLPYRIDINYL OF FORMULA (I) WHERE R IS H OR TOGETHER WITH R1 AND THE N TO WHICH THEY ARE UNITED FORM A PYRROLIDINE OR PIPERIDINE; R1 IS ALKYL (C3-C8), ALKENYL (C3-C8), 5 TO 6 MEMBER HETEROCYCLE, AMONG OTHERS; R2a AND R2b ARE EACH H; R3 IS H, HALO, (C1-C3) ALKYL, OH, AMONG OTHERS; R4 IS H, HALO, ALCOXY (C1-C3), FLUORESUSTITUTED METHYL, AMONG OTHERS; V IS N OR CR5, WHERE R5 IS H, HALO, ALKYL (C1-C3), AMONG OTHERS; R6 IS H, (C1-C3) ALKYL, HALO, AMONG OTHERS; R7 IS H, F, OH, -C (O) NH2, AMONG OTHERS; R8 IS -C (O) NH2, -NHSO2 (C1-C4) ALKYL, OH, AMONG OTHERS; R9 IS H, HYDROXYL, (C1-C3) ALKYL, HALO, AMONG OTHERS; W IS CR10 O N, WHERE R10 IS H, ALKYL (C1-C3), HYDROXYL, CN, AMONG OTHERS; X IS N O CR11, WHERE R11 IS H, ALKYL (C1-C3), HYDROXYL, HALO, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2-CHLORO-3 ', 5'-DIFLUORO-4' - ({[2- (TETRAHYDRO-2H-PYRAN-4-IL) ETHYL] -AMINO} -MEthyl) -BIPHENYL-4-CARBOXAMIDE, 3 ', 5'-DIFLUORO-2-METHYL-4' - ({[(2S) -TETRAHYDROFURAN-2-ILMETHYL] -AMINO} -MEthyl) -BIPHENYL-4-CARBOXAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF THE OPIOID RECEPTORS ยต,? AND d BEING USEFUL IN THE TREATMENT OF OBESITY |