| abstract |
REFERRING TO A HETEROARYL COMPOUND OF FORMULA (I), WHERE X IS CH, N OR NO; Y IS CH, N, NO, WITH THE CONDITION THAT X AND Y ARE NOT BOTH CH OR NOT; A IS F, Cl, NR2, C1-C3 ALKYL, AMONG OTHERS; G IS AN ARYL OR HETEROARYL GROUP, WHERE G IS REPLACED BY ONE OMAS R1, R2 OR R3; Ar IS AN ARYL OR HETEROARY GROUP OF 6 MEMBERS; L1 IS C (O) NH; L2 IS A COVALENT LINK, (CR'2) s, (CR'2) nO (CR'2) t, AMONG OTHERS; Q IS ALKYL, CYCLOALKYL, ARYL, AMONG OTHERS; R1 IS F, Cl, NR2, CN, AMONG OTHERS; R2 IS Cl, CN, NO2, OR, AMONG OTHERS; R3 IS RENTAL, ALKENYL, ALKINYL, AMONG OTHERS; R IS H, C1-C6 ALKYL, AMONG OTHERS; R 'IS H, ALKYL, CYCLOALKYL, AMONG OTHERS; n IS 0, 1 O 2; s IS 1,2 O3; t IS 0, 1 O 2; WITH THE CONDITION THAT THE COMPOUND IS NOT 5- (BIPHENYL-4-IL) -6-CHLORO-N- (6-METOXIPIRIDIN-3-IL) NICOTINAMIDE. PREFERRED COMPOUNDS ARE: 3-TER-BUTYL-5-CYAN-N- (6-METHYL-5- (3- (NEOPENTILCARBAMOIL) PHENYL) -PYRIDIN-3-IL) BENZAMIDE, N- (5- (4- (BENZYLOXY ) PHENYL) -6-METHYLPYRIDIN-3-IL) -3-TER-BUTYL-5-CYANOBENZAMIDE, 3-TER-BUTYL-5-CYANE-N- (5- (4- (3,3-DIMETHYL-2- OXOBUTOXI) PHENYL) -6-METHYLPYRIDIN-3-IL) BENZAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE INHIBITORS OF CYTOKINE AND ARE USEFUL IN THE TREATMENT OF AUTOIMMUNE, INFLAMMATORY, CANCER, AMONG OTHERS |