| abstract |
REFERRING TO A DIARYLIC ETHER DERIVATIVE OF FORMULA (I), WHERE R1 IS H OR METHYL; R2 IS C3-C10 ALKYL, 5 TO 6 MEMBER CYCLOALKYL OPTIONALLY CONDENSED TO A BENZENE RING O (CH (R)) m (CH2) n-A, WHERE m IS 1; n IS 0, 1 O 2; R IS H, METHYL OR ETHYL; A IS C1-C4 ALCOXY, PHENOXY, PHENYL, AMONG OTHERS; R4 IS H O HALOGEN; R5 IS H O HALOGEN. PREFERRED COMPOUNDS ARE: 4- {2-FLUORO-4 - [(3-METHYL-BUTYLAMINE) -MEthyl] -PHENOXY} -2-HYDROXY-BENZAMIDE, 4- {2,6-DIFLUORO-4 - [(3-METHYL -BUTYLAMINO) -MEthyl] -PHENOXY} -2-HYDROXY-BENZAMIDE, 4- [2-FLUORO-4- (INDAN-2-ILAMINOMETHYL) -PHENOXY] -2-HYDROXY-BENZAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF MU, KAPPA AND DELTA OPIOID RECEPTORS AND ARE USEFUL IN THE TREATMENT OF OBESITY AND RELATED DISEASES |