| abstract |
REFERS TO BENZOXAZOLE AND BENZOTHIAZOLE 6-O-SUBSTITUTED COMPOUNDS FOR FORMULA (I), WHERE X IS O, S or S (O); R1 AND R2 ARE INDEPENDENTLY H, ALKYL, ACIL, CYCLOALKYL, ARYL, HETEROCYCLYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED; R3 IS H, HALO, ALKENYL, ACYLAMINE, AMINOCARBONYL, AMONG OTHERS; R6 IS ALKYL, ALCOXY, AMONG OTHERS; n IS 0.1 O 2; WHEN X IS O, R4 IS H, ALKENYL, ALKYL SUBSTITUTED, AMONG OTHERS AND R5 IS H, ALKYL, ALKENYL, AMONG OTHERS; OR R4 AND R5 TOGETHER FORM A HETEROCYCLYL, CYCLOALKYL, ARYL, AMONG OTHERS, OPTIONALLY REPLACED. THEY ARE SELECTED: 4- [2- (4-BROMO-PHENYLAMINE) -BENZOOXAZOL-6-ILOXI] -PYRIDIN-2-CARBOXYL ACID METHYLAMIDE, (2,3-DIHYDRO-BENZO [1,4] DIOXIN-6-IL ) - [6- (6,7-DIMETOXI-QUINOLIN-4-ILOXI] -BENZOOXAZOL-2-IL] -AMINE; AMONG OTHERS. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE INHIBITORS OF CSF -1R, AND THEY ARE USEFUL FOR THE TREATMENT AND PREVENTION OF CANCER, TUMORS, DEGENERATIVE BONE DISEASES SUCH AS RHEUMATOID ARTHRITIS |