abstract |
REFERRING TO A PYRAZOLO- [3,4-d] -PYRIMIDINE COMPOUND OF FORMULA (I), WHERE R1 IS C1-C3 ALKYL OPTIONALLY SUBSTITUTED WITH ONE TO SEVEN ATOMS OF FLUOR; R2 IS A HETEROARYL GROUP OF 5 TO 6 MEMBERS OR A PHENYL, OPTIONALLY REPLACED BY A CIANO GROUP, C1-C8 ALKYL, A NITRO GROUP, AMONG OTHERS; R3 IS H, AMINO OR C1-C3 ALKYL-AMINO; Y IS H, C1-C8 ALKYL, C1-C8 ALCOXYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 3- (3-FLUORO-4-METOXY-PHENYL) -1-METHYL-1H-PYRAZOLO- [3,4-d] -PYRIMIDIN-6-IL-AMINE, 3-BENZO [1,3] DIOXOL-5-IL-1-METHYL-1H-PYRAZOLE- [3,4-d] -PYRIMIDIN-6-IL-AMINE, 3- (3-FLUORO-PHENYL) -1-METHYL-1H-PYRAZOLE- [3 , 4-d] -PYRIMIDIN-6-IL-AMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF PHOSPHATIDYL-INOSITOL-3 KINASE (KINASE PI-3) AND ARE USEFUL IN THE TREATMENT OF INFLAMMATORY OR OBSTRUCTIVE DISEASES OF THE RESPIRATORY TRACT. |