| abstract |
REFERRING TO A BENZOHETEROARYLSULFAMIDE DERIVATIVE OF FORMULA (I), WHERE R1 IS H, HALOGEN, OH, METOXY, NITRO, AMONG OTHERS; XY IS -S-CH-, -O-CH-, -O-C (CH3) -, AMONG OTHERS; A IS -CH2- O -CH (CH3) -; R2 IS H O METHYL; R3 AND R4 ARE HO ALKYL C1-C4 OR TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE UNITED, THEY FORM A RING OF 5 TO 7 MEMBERS OPTIONALLY SUBSTITUTED WITH O, NOT S. -YLMETHYL) -SULFAMIDE, N - [(5-CHLOROBENZO [b] HAVE-3-IL) METHYL] -SULFAMIDE, N - [(5-FLUOROBENZO [b] HAVE-3-IL) METHYL] -SULFAMIDE, AMONG OTHERS . SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF EPILEPSY AND RELATED DISORDERS. IT ALSO REFERS TO A PHARMACEUTICAL COMBINATION THAT INCLUDES THE COMPOUNDS OF FORMULA (I) AND ANOTHER ANTIEPILEPTIC AGENT SUCH AS CARBAMAZEPINE, CLOBAZAM, CLONAZEPAM, GABAPENTINE, FENITOIN, AMONG OTHERS |