| abstract |
REFERS TO A COMPOUND OF FORMULA II WHERE x IS 0-3; and ES 0-5; R1 IS -R, CN, HALOGEN, -OR; R IS H, C1-C6 ALIPHATIC, C1-C6 HALOALIPHATE; R2 IS PHENYL, HALOGEN, CN, R, OR. PREFERRED COMPOUNDS ARE: (R) -2- (AMINomethyl) -8- (2,6-DICHLOROPHENYL) CHROMANE HYDROCHLORIDE; (2R) -2- (BROMOMETHYL) -6-FLUORO-8- (2-TRIFLUOROMETHYL) PHENYL CHROMANE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THE COMPOUNDS DESCRIBED ARE AGONISTS OR PARTIAL AGONISTS OF THE BRAIN SEROTONIN RECEPTORS SUBTYPE 2C, USEFUL IN THE TREATMENT OF A VARIETY OF CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS SCHIZOPHRENIA |