| abstract |
IT REFERS TO A FORMULATION THAT CONTAINS: A) A PROTEIN SELECTED FROM ANTIBODY SUCH AS ANTIB7.1, ANTIB7.2, ANTI CD22, COAGULATION FACTOR, ENZYME, TRANSCRIPTION FACTOR, AMONG OTHERS IN A CONCENTRATION OF 0.1 mg / ml AND 300 mg / ml; B) SURFACTANT SELECTED FROM POLYSORBATE-20 OR POLYSORBATE-80; C) AMINO ACID SELECTED FROM ARGININE, LYSINE, GLYCINE, GLUTAMIC ACID, AMONG OTHERS; C) TONICITY MODIFIER SELECTED AMONG SODIUM CHLORIDE, MANNITOL, SORBITOL. ADDITIONALLY IT INCLUDES A SELECTED SUGAR OF SACROSE, TREHALOSE AND MANNITOL. METHIONINE IS ADDED TO SUCH FORMULATION AT A CONCENTRATION OF 0.5mM AND 145mM IN ORDER TO GET A REDUCED AGGLOMERATION OF PROTEIN IN THE FORMULATION COMPARED TO PROTEIN IN A FORMULATION THAT LACKS METHIONINE |