| abstract |
AMIDE DERIVATIVE OF FORMULA (I), WHERE R4 IS H, F, OH, OCH2CH3, AMONG OTHERS; R2 IS CYCLOALKYL, THIOPHENYL, FURANIL, AMONG OTHERS; Z IS H, F, or CH3; J IS CH O N; Rz AND Ry SON H, C1-C4 ALKYL, AMONG OTHERS; R3 IS H, C1-C4 ALKYL, CH2CH2NH2, AMONG OTHERS; R1 IS C1-C4 ALKYL, CN, SO2CH3, AMONG OTHERS. FAVORITE COMPOUNDS ARE: [2- (4,4-DIMETHYL-CYCLOHEX-1-ENYL) -4- (4-HYDROXY-TETRAHYDRO-THIOPYRAN-4-IL) -PHENYL] -AMIDE OF 4-CYANE-1H-IMIDAZOLA -2-CARBOXYL, [2-CYCLOHEX-1-ENYL-4- (4-HYDROXY-TETRAHYDROPYRAN-4-IL) -PHENYL]-4-CYANE-1H-IMIDAZOLE-2-CARBOXYL ACID AMIDE, [2-CYCLOHEX -1-ENIL-4- (4-HYDROXY-1,1-DIOXOHEXAHYDRO-1,6-THIOPYRAN-4-IL) -PHENYL] -AMIDE OF 4-CYANE-1H-IMIDAZOL-2-CARBOXYL ACID, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF PROTEIN TYROSINE KINASES, PARTICULARLY KINASE C-FMS, AND ARE USEFUL IN THE TREATMENT OF AUTOIMMUNE DISEASES, CANCER METASTASES, PIAGET'S DISEASE, AMONG OTHERS |