| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R1 IS ALKYL, BENZYL OPTIONALLY SUBSTITUTED, R2 IS H, ALKYL OR BENZYL OPTIONALLY SUBSTITUTED; OR TOGETHER R1 AND R2 TOGETHER TO THE NITROGEN ATOM, HETEROCYCLE OPTIONALLY REPLACED; R3 IS HALOGEN, HYDROXYL, ALKYL, ALCOXYL, AMINE, AMONG OTHERS; R4 IS HYDROXYL, HALOGEN, AMINE, ALKYL-AMINE, AMONG OTHERS; Q IS CH, CR4, N; V IS CH, CR4, N; X IS CH, N; Y IS CH, CR3, N; Z IS CR6aR6b, NR5, O; R5 IS H, HYDROXYL; R6a AND R6b ARE EACH H, HALOGEN, HYDROXYL, AMINE, ALKYL, ALCOXYL, HALOALKYL. THE PREFERRED COMPOUNDS ARE: 6- (4-CHLORO-PHENYL-AMINE) -N, N-DIETHYL-NICOTINE-AMIDE HYDROCHLORIDE; N, N-DIETHYL-6- (4-METOXY-PHENYL-AMINO) -NICOTIDIN-AMIDE HYDROCHLORIDE; AZEPAN-1-IL- [6- (4-CHLORO-PHENYL-AMINO) -PYRIDIN-3-IL] -METHANONE; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF HUMAN METABOTROPIC GLUTAMATE RECEPTORS (mGLURs) USEFUL IN DIFFERENT DISORDERS RELATED TO THE GASTROINTESTINAL AND URINARY TRACT AS WELL AS DISORDERS OF THE NERVOUS SYSTEM |