| abstract |
REFERRING TO A COMPOUND DERIVED FROM INDOLE OF FORMULA (I), WHERE A AND Ar ARE ARYL, HETEROARYL, AMONG OTHERS; R1 IS H, ALKYL, AMONG OTHERS; X IS N, N-OXIDE OR CR12; L IS A LINK, CO, CO-NH, NH-SO, NH-CO-NH, AMONG OTHERS; R5, R6, R7 AND R12 ARE H, HALOGEN, CF3, NO2, AMONG OTHERS; Q IS H, CH3 OR CYCLOPROPYL. PREFERRED COMPOUNDS ARE: 3- {4- [3- (2-FLUORO-5-TRIFLUOROMETHYL-PHENYL) -UREIDO] -PHENYL} -1H-INDOL-2-CARBOXAMIDE, 3- {4- [3- (2-FLUORO -5-TRIFLUOROMETHYL-PHENYL) -UREIDO] -PHENYL} -1H-PIRROLO [3,2-b] PYRIDIN-2-CARBOXAMIDE, 3- [4- (3-PHENYL-UREIDO) -PHENYL] -1H-INDOL- 2-CARBOXAMIDE, AMONG OTHERS. IT ALSO REFERS TO A COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE MODULATORS OF KINASE ACTIVITY, PREFERENCING KDR AND Tie2 AND ARE USEFUL IN THE TREATMENT OF CANCER |