| abstract |
REFERS TO COMPOUNDS DERIVED FROM TETRAHIDRONAPHTHALINE OF FORMULA (Ia) WHERE R1 AND R2 ARE EACH H, HYDROXYL, HALOGEN, PERFLUOROALKYL (C1-C5), ALKYLTIOL (C1-C5), AMONG OTHERS; R3 IS H, HYDROXYL, HALOGEN, CN, ALKYL (C1-C10) OPTIONALLY SUBSTITUTED WITH OH, CN, NITRO, HALOGEN, AMONG OTHER SUBSTITUENTS, AMONG OTHERS; R4 IS ALKYL (C1-C10) OPTIONALLY SUBSTITUTED WITH 1-3 HYDROXYL, HALOGEN OR ALCOXYL (C1-C5), CYCLOALKYL (C3-C7), ARYL (C6-C14), AMONG OTHERS; R5 IS ALKYL (C1-C10) OPTIONALLY FLUORATED, CYCLOALKYL (C3-C7), ALKYL (C1-C8) CYCLOALKYL (C3-C7), HETEROCYCLYL, AMONG OTHERS; R6 IS METHYL, ETHYL, PROPYL, ISOPROPYL, OR ETHYLENE. PREFERRED COMPOUNDS ARE: (5a, 6a, 8ß) -2-FLUORO-8-METHYL-5 - [(2-METHYLQUINOLIN-5-IL) AMINO] -6- (TRIFLUORMETHYL) -5,6,7,8-TETRAHYDRONAPHTHALIN -1,6-DIOL, (5a, 6a, 8ß) -2-FLUORO-5 - [(8-FLUORO-2-METHYLQUINAZOLINE-5-IL) AMINO] -8-METHYL-6- (TRIFLUORMETHYL) -5, 6,7,8-TETRAHIDRONAPHTHALIN-1,6-DIOL, (5a, 6a, 8ß) -5 - [(7,8-DIFLUORO-2-METHYLQUINAZOLIN-5-IL) AMINO] -2-FLUORO-8-METHYL -6- (TRIFLUORMETHYL) -5,6,7,8-TETRAHIDRONAFTALIN-1,6-DIOL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS INHIBIT THE SECRETION OF IL-8 CYTOKININE, BEING USEFUL FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, BRONCHITIS, RHEUMATIC DISEASE, PSORIASIS |