| abstract |
REFERS TO COMPOUNDS DERIVED FROM DIBENCILAMINE OF FORMULA (I) WHERE IS -COOALKYL (C1-C4), CN, -CHO, -CONH2, AMONG OTHERS; B IS -NR15R16 OR A 3 TO 8 MEMBER HETERO CYCLE THAT HAS 1 OR 2 HETEROATOMS SELECTED FROM O, NYS OPTIONALLY SUBSTITUTED WITH R20, WHERE R20 IS HALO, OXO, ALKENYL (C2-C6), ALKYL (C1T-C6) OTHERS; R15 AND R16 ARE EACH H, ALKYL (C2-C6), ALKYL (C1-C6), CN, AMONG OTHERS; X IS C O N; AND IS -CR11R12, WHERE R11 IS H, ARYL, AMONG OTHERS; R12 IS H; R1, R2, R3, R4, R5, R6 AND R7 ARE EACH H, HALO, CN, HYDROXY, NITRO, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N- [3,5-BIS (TRIFLUORomethyl) BENZYL] -2-METHYL-N- [2- (1-MORPHOLIN-4-IL-PROPYL) -5- (TRIFLUOROMETIL) BENZYL] -2H-TETRAZOLE -5-IL-AMINE, (R) -N- [3,5-BIS (TRIFLUOROMETIL) BENZYL] -2-METHYL-N- [2- (1-MORFOLIN-4-IL-PROPIL) -5- (TRIFLUOROMETIL) ) BENZYL] -2H-TETRAZOL-5-IL-AMINE, N- [3,5-BIS (TRIFLUORomethyl) BENZYL] -2-METHYL-N- [2- (2-METHYL-1-MORFOLIN-4-ILPROPIL) -5- (TRIFLUOROMETIL) BENZYL] -2H-TETRAZOLE-5-IL-AMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN (CEPT) RAISING PLASMA LEVELS OF HIGH DENSITY LIPOPROTEINS (HDL) BEING USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS, CORONARY ARTERIOPATIA, CORONARY DYSTIA |