| abstract |
REFERS TO COMPOUNDS DERIVED FROM 2-CARBOXYTHIOPHENE OF FORMULA (I) WHERE A IS HYDROXY; R1 IS -RX-RY-, WHERE RX IS PHENYL OPTIONALLY SUBSTITUTED WITH HALO, METHYL, ETHYL, METOXY OR TRIFLUOROMETHYL, OR HETEROARYL OF 5 TO 6 MEMBERS JOINED THROUGH A CARBON ATOM OF THE CARBON RING TO THE ATOMO; RY IS 8, 9 OR 10-MEMBER HETEROARYL; R2 IS CYCLOALKYL (C5-C7) OPTIONALLY SUBSTITUTED WITH ALKYL (C1-C6) OR -ORA, WHERE RA IS H OR ALKYL (C1-C6); R3 IS ALKYL (C1-C6) OPTIONALLY SUBSTITUTED WITH CYCLOALKYL (C3-C6). THE PREFERRED COMPOUNDS ARE: 5- (4-FURO [3,2-b] PYRIDIN-2-ILPHENYL) -3 - [[(TRANS-4-METHYL CYCLOHEXYL) CARBONYL] (1-METHYLETHYL) AMINO] -2-THIOPHENOCARBOXYL ACID, 5- (4-IMIDAZO [1,2-a] PYRIDIN-2-ILPHENYL) -3 - [[(TRANS-4-METHYL CYCLOHEXYL) CARBONYL] (1-METHYLETHYL) AMINO] -2-THIOPHENOCARBOXYL ACID, 5- ( 4-IMIDAZO [2,1-b] [1,3] THIAZOL-6-ILPHENYL) -3 - [[(TRANS-4-METHYL CYCLOHEXYL) CARBONYL] (1-METHYLETHYL) AMINO] -2-THIOPHENOCARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE HEPATITIS C VIRUS POLYMERASE (HCV) AND ARE USEFUL IN THE TREATMENT OF AN INFECTION PRODUCED BY THE HEPATITIS C VIRUS |