| abstract |
REFERS TO COMPOUNDS DERIVED FROM PYRAZOLO [1,5-a] PYRIMIDINE SUCH AS COMPOUNDS OF FORMULA (I), (II), (III), AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION INCLUDING: A) A COMPOUND DERIVED FROM PYRAZOLO [1,5-a] PYRIMIDINE; AND B) AN ANTI-CANCER AGENT SUCH AS TEMOZOLOMIDE, DOXORUBICIN, TAXOL, ETOPOSIDE, AMONG OTHERS. SAID COMPOUNDS ARE INHIBITORS OF CYCLINE-DEPENDENT KINASES CDK1, CDK2 OR CDK3, BEING USEFUL IN THE TREATMENT OF BLADDER, BREAST, COLON, LEUKEMIA, MYELOMA CANCERS |