| abstract |
REFERS TO COMPOUNDS OF FORMULA (I) OR ITS TAUTOMER OF FORMULA (I ') WHERE R1 IS H, ALKYL (C1-C10), CYCLOALKYL (C3-C12), AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH H, HALO, OH, AMONG OTHERS; R2 IS HALO, CN, ALKYL (C1-C10), AMONG OTHERS; R3 IS H, ALKYL (C1-C10), PHENYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH HALO, OH, CN, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5 (R, S), 7 (R, S) -8-BENZYL-4- (CYCLOHEXYLAMINE) -1- (3-FLUOROPHENYL) -7-METHYL-1,3,8-TRIAZAESPIRO [4, 5] DEC-3-EN-2-ONA RACEMICA (DIASTEREOMER A), 5 (R, S), 7 (S, R) -8-BENZYL-4- (CYCLOHEXYLAMINE) -1- (3-FLUOROPHENYL) -7 -MEthyl-1,3,8-TRIAZAESPIRO [4,5] DEC-3-EN-2-ONA RACEMICA (DIASTEREOMER B), 5 (R, S), 7 (R, S) -4- (CYCLOHEXYLAMINE) - 1- (3-FLUOROPHENYL) -8- (3-ISOPROPOXIBENZYL) -7-METHYL-1,3,8-TRIAZAESPIRO [4,5] DEC-3-EN-2-ONA RACEMICA (DIASTEREOMER A), AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE BETA SECRETASE ENZYME, BEING USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE |