| abstract |
REFERRED TO A COMPOUND OF FORMULA (I), WHERE A IS AN OPTIONALLY SUBSTITUTED AROMATIC RING; Ar IS AN OPTIONALLY REPLACED SINGLE CYCLE RING; R1 IS AN OPTIONALLY SUBSTITUTED HETEROCYCLIC GROUP OR A HYDROCARBON GROUP SUCH AS C1-C10 ALKYL, C2-C10 ALKYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH C3-C10 CYCLOALKYL, OTHERS, BETWEEN; R2 IS H, AN OPTIONALLY SUBSTITUTED HETEROCYCLIC GROUP OR A HYDROCARBON GROUP SUCH AS C1-C10 ALKYL, C6-C14 ARYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH C3-C10 CYCLOALKYL, THYENYL, PYRIDYL; X IS A SPACER THAT HAS A MAIN CHAIN OF 1 TO 2 ATOMS; AND IT IS A LINK OR A SPACER WITH A CHAIN OF 1 OR 2 ATOMS; W IS A DIVALENT HYDROCARBON GROUP SUCH AS C1-C20 ALKYLENE, C2-C20 ALKYLENE, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH HALOGEN, OH, AMONG OTHERS; Z IS CONRaSO2, SO2NRaCO, SO2NRaCOO, AMONG OTHERS, WHERE Ra IS H, A HYDROCARBON GROUP, AN AMINO PROTECTIVE GROUP, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 3- (2 - {[3-CHLORO-5- (TRIFLUOROMETHYL) PYRIDIN-2-IL] OXI} -4-ISOPROPOXIFENIL) -N- (PENTILSULFONIL) PROPANAMIDA, (2E) -3- [2- {[3-CHLORO-5- (TRIFLUOROMETHYL) PYRIDIN-2-IL] OXI} -4- (2-METOXYETOXY) PHENYL] -N- (PENTILSULFONIL) ACRYLAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ACT ON RETINOID X RECEPTORS (RXR) AND RECEPTORS ACTIVATED BY PEROXISOMAS PROLIFERATORS (PPAR) AND ARE USEFUL IN THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, AMONG OTHERS |